Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms.
- Author:
Young Beak KIM
1
;
Sun Young LEE
;
Jeong Hwan KIM
;
In Kyung SUNG
;
Hyung Seok PARK
;
Chan Sup SHIM
;
Hye Seung HAN
Author Information
- Publication Type:Research Support, Non-U.S. Gov't ; Original Article
- Keywords: Microsatellite instability; Stomach neoplasms; Colorectal neoplasms; Adenoma
- MeSH: Adenoma/*genetics/surgery; Aged; Colonoscopy; Colorectal Neoplasms/*genetics/surgery; Endoscopy, Digestive System; Female; Humans; Male; *Microsatellite Instability; Middle Aged; Neoplasms, Multiple Primary/*genetics/surgery; Predictive Value of Tests; Stomach Neoplasms/*genetics/surgery
- From:Gut and Liver 2016;10(2):220-227
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms. METHODS: Consecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers. RESULTS: In total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSI-L], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included. Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987). CONCLUSIONS: The presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.
