Small cell malignant tumors of bone: comparison between diagnosis using core needle biopsies and surgical specimens.
- Author:
Yi DING
1
;
Yue XI
;
Xiao-qi SUN
;
Shu-qin MENG
;
Wei-feng LIU
;
Xiao-yuan HUANG
Author Information
- Publication Type:Journal Article
- MeSH: 12E7 Antigen; Adolescent; Adult; Aged; Antigens, CD; metabolism; Biopsy, Large-Core Needle; Bone Neoplasms; diagnosis; metabolism; pathology; Carcinoma, Small Cell; diagnosis; metabolism; pathology; Cell Adhesion Molecules; metabolism; Child; Female; Humans; Lymphoma; diagnosis; metabolism; pathology; Male; Middle Aged; Neuroectodermal Tumors, Primitive, Peripheral; diagnosis; metabolism; pathology; Oncogene Proteins, Fusion; metabolism; Osteosarcoma; diagnosis; metabolism; pathology; Plasmacytoma; diagnosis; metabolism; pathology; Proto-Oncogene Protein c-fli-1; metabolism; RNA-Binding Protein EWS; metabolism; Retrospective Studies; Sarcoma, Ewing; diagnosis; metabolism; pathology; Vimentin; metabolism; Young Adult
- From: Chinese Journal of Pathology 2013;42(3):163-167
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the pathologic diagnosis and immunohistochemistry of small cell malignant tumors (SCMT) of bone using both core needle biopsy and surgical specimen.
METHODSSeventy-seven cases of SCMT with core needle biopsies and surgical specimens available were respectively analyzed by histologic examination and immunohistochemical study, with literature review.
RESULTSThe male-to-female ratio was 48:29. The age of the patients ranged from 6 to 73 years. The tumors studied included Ewing sarcoma/PNET (n = 38), myeloma (n = 23), lymphoma (n = 10), small cell osteosarcoma (n = 2), small cell carcinoma (n = 2) and mesenchymal chondrosarcoma (n = 2). The tumors involved limbs, axial skeleton and flat bones. Microscopically, the tumors shared similar histology, with small round cells and spindly cells arranged in diffuse sheets. The pathologic diagnosis by core needle biopsies correlated with that by surgical specimens in 84.4% (65/77) of the cases.
CONCLUSIONSSCMT represents a heterogeneous group of malignancy. Correlations with clinicoradiologic findings and application of ancillary investigations including immunohistochemistry and molecular study are important for definitive diagnosis. Pathologic diagnosis using core needle biopsies shows good results and provides useful information for surgical planning.
