Analysis of the proteomic changes of the serum of the Smad3 targeted deficient mice.
- Author:
Zhen-Ming HAO
1
;
Xiao YANG
;
Wan-Tao YING
;
Jie WANG
;
Xiao-Hong QIAN
;
Cui-Fen HUANG
Author Information
1. Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
- Publication Type:Journal Article
- MeSH:
Animals;
DNA-Binding Proteins;
blood;
deficiency;
genetics;
Electrophoresis, Gel, Two-Dimensional;
Electrophoresis, Polyacrylamide Gel;
Genotype;
Mice;
Mice, Knockout;
Peptide Mapping;
Proteome;
analysis;
Smad3 Protein;
Trans-Activators;
blood;
deficiency;
genetics
- From:
Chinese Journal of Biotechnology
2002;18(4):452-456
- CountryChina
- Language:Chinese
-
Abstract:
We have studied the proteomic changes of the serum of the Smad3 targeted deficient mice using 2-DE and PMF approaches. 7 proteins expressed at different level in wild type mice and the Smad3 deficient mice were identified. These results would benefit the research on diagnosis and therapy of osteoarthritis and provided clues to studying the important function of Smad3 mediated TGF-beta signals during the skeletal development.
