Genetic Characteristics and Immunogenicity of Pandemic H1N1 Influenza Virus Isolate from Pig in Korea.
- Author:
Hyoung Joon MOON
1
;
Jin Sik OH
;
Woonsung NA
;
Minjoo YEOM
;
Sang Yoon HAN
;
Sung Jae KIM
;
Bong Kyun PARK
;
Dae Sub SONG
;
Bo Kyu KANG
Author Information
- Publication Type:Brief Communication
- Keywords: Influenza; Pig; Vaccine; H1N1
- MeSH: Agriculture; Animals; Cell Line; Eggs; Guinea Pigs; Influenza Vaccines; Influenza, Human*; Kidney; Korea*; Orthomyxoviridae*; Ovum; Pandemics*; Seroconversion; Swine
- From:Immune Network 2016;16(5):311-315
- CountryRepublic of Korea
- Language:English
- Abstract: A pandemic influenza A (H1N1) virus strain was isolated from a pig farm in Korea in December 2009. The strain was propagated in and isolated from both the Madin-Darby canine kidney cell line and embryonated eggs. The partial and complete sequences of the strain were identical to those of A/California/04/2009, with >99% sequence similarity in the HA, NA, M, NS, NP, PA, PB1, and PB2 genes. The isolated strain was inactivated and used to prepare a swine influenza vaccine. This trial vaccine, containing the new isolate that has high sequence similarity with the pandemic influenza A (H1N1) virus, resulted in seroconversion in Guinea pigs and piglets. This strain could therefore be a potential vaccine candidate for swine influenza control in commercial farms.
