Anti-inflammatory mechanism analysis of antirheumatic Chinese medicinal herb Aconiti Radix based on protein interaction network.
10.19540/j.cnki.cjcmm.20170121.031
- Author:
Shi-Chao ZHENG
1
;
Xiao-Ying YAN
1
;
Ju CHEN
1
;
Shu-Ting ZHAO
1
;
Chuan-Biao WEN
1
Author Information
1. School of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
- Publication Type:Journal Article
- Keywords:
Aconiti Radix;
anti-inflammatory mechanism;
functional modules;
protein interaction network;
rheumatism
- From:
China Journal of Chinese Materia Medica
2017;42(9):1747-1751
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation is one of the important risk factors of rheumatic diseases. Aconiti Radix is widely used for the treatment of rheumatism, which has significant anti-inflammatory effects. However, its anti-inflammatory mechanism on molecular level is still not clear. The purpose of this study is to illuminate the anti-inflammatory mechanism of Aconiti Radix based on the protein interaction network (PIN) analysis on molecular network level. The main anti-inflammatory components (aconitine, hypaconitine and mesaconitine) were chosen in this study to obtain the targets of the components and protein-protein information though databases retrieval and construct the PIN of Aconiti Radix. By a graph theoretic clustering algorithm molecular complex detection(MCODE), 13 modules were identified and analyzed by gene ontology(GO) enrichment. The results showed that the anti-inflammatory mechanism of Aconiti Radix was mainly associated with prostanoid metabolic process and leukocyte chemotaxis mediated by chemokines. In this study, the anti-inflammatory mechanism of Aconiti Radix was elucidated systematically from molecular network level, which provided the scientific basis for the treatment of rheumatic diseases.
