Absorption enhancing effects and safety of PAMAM dendrimers on liquiritin.
10.19540/j.cnki.cjcmm.2017.0070
- Author:
Wen-Jun QU
1
;
Hui-Fang LI
2
;
Yuan-Yuan SU
2
;
Zheng-Qi DONG
2
;
Yan-Ru GE
1
Author Information
1. Jiangsu University, Zhenjiang 212000, China.
2. Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Beijing 100193, China.
- Publication Type:Journal Article
- Keywords:
Caco-2 cells;
PAMAM dendrimers;
absorption enhancer;
liquiritin
- From:
China Journal of Chinese Materia Medica
2017;42(9):1766-1771
- CountryChina
- Language:Chinese
-
Abstract:
PAMAM dendrimer is one of the most widely studied dendrimers in recent years, which has a large number of functional groups on the surface and cavities inside, specific three-dimensional structure and good biocompatibility, permeability and stability. It has been widely applied in drug and gene carrier fields and may become a new absorption enhancer. In order to study the absorption enhancing effects of PAMAM dendrimers, liquiritin was selected as the model drug, with the protection of spleen and liver, detoxification and other functions, but it had not been widely used in clinical application because of its difficult absorption, first pass effect, and low bioavailability. This topic was based on the two main determinants (solubility and permeability) of intestinal absorption in the body, researched the physicochemical properties of liquiritin, analyzed the transport volume of liquiritin with or without PAMAM dendrimers by using Caco-2 cell model, and analyzed the cytotoxicity of PAMAM dendrimers on Caco-2 cells by MTT experiments. These results showed that 0.1% of the G4 generation PAG can promote the absorption of liquiritin safely and effectively, and it was suitable for further development into a new type of pharmaceutical excipients.
