Nasal resorption of prim-O-glucosylcimifugin and 5-O-methylvisammioside in rats.
10.19540/j.cnki.cjcmm.20170224.001
- Author:
Tong-Fang WANG
1
;
Jian-Ping WANG
2
;
Jin-Huo PAN
1
;
Zhi-Tao JIANG
2
;
Xiao-Feng CHEN
2
;
Jian-Chun WANG
2
Author Information
1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. Graduate Workstation of Enterprises in Jiangsu Province, Zhangjiagang Hospital of Traditional Chinese Medicine Group Corporation, Zhangjiagang 215600, China.
- Publication Type:Journal Article
- Keywords:
5-O-methylvisammioside;
nasal circulatory perfusion;
prim-O-glucosylcimifugin
- From:
China Journal of Chinese Materia Medica
2017;42(9):1772-1776
- CountryChina
- Language:Chinese
-
Abstract:
In this experiment, rat nasal mucosa absorption characteristics of prim-O-glucosylcimifugin and 5-O-methylvisammioside were studied to provide a basis for drug delivery of Toutongning nasal spray. The nasal mucosa absorption test in rats was conducted with in situ nasal perfusion method after pH 6 buffer solution was used to prepare high, medium and low concentrations of prim-O-glucosylcimifugin, 5-O-methylvisammioside mixed solution as liquid circulation in nasal cavity. Then the concentrations of the circulating liquid compositions to be measured were determined by HPLC, and the absorption rates of prim-O-glucosylcimifugin and 5-O-methylvisammioside under different pH conditions were also investigated. According to the results, the absorption rate constant was (0.588±0.041)×10⁻³, (0.547±0.023)×10⁻³, (0.592±0.063)×10⁻³ min⁻¹ for prim-O-glucosylcimifugin high, middle and low concentrations, and (0.438±0.041)×10⁻³, (0.407±0.023)×10⁻³, and (0.412±0.063)×10⁻³ min⁻¹ for 5-O-methylvisammioside high, middle and low concentrations. There was no significant difference among high, middle and low concentration groups, and the absorption under pH 6 was better than that under other pH conditions. Therefore, we can get the conclusion that the main active ingredient of Toutongning nasal sprays can be absorbed through the nasal mucosa, and it is feasible to make nasal spray; in addition, pH 6 of nasal spray is scientific and reasonable.
