Research progress of 5-hydroxymethylfurfural, a safety-related substance in traditional Chinese medicine injections.
10.19540/j.cnki.cjcmm.2017.0074
- Author:
Zhuo PAN
1
;
He-Xin SHAO
1
;
Ting LIU
1
;
Xiao-Yan LU
1
;
Xiao-Hui FAN
1
Author Information
1. Department of Chinese Medicine Science & Engineering, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- Keywords:
5-hydroxymethylfurfural;
limit standard;
toxiceffects;
traditional Chinese medicine injection
- From:
China Journal of Chinese Materia Medica
2017;42(10):1842-1846
- CountryChina
- Language:Chinese
-
Abstract:
Screening out the safety-related substances and establishing the corresponding standard has been a key research issue to improve the safety of traditional Chinese medicine injections(TCMIs). 5-HMF which widely exists in sugar-containing TCMIs has long been considered as an important safety-related substance. In this review, we summarizes the research progress on the toxicology of 5-HMF as well as the content and standards of 5-HMF in TCMIs.Therein, both literature summary and analysis results indicate that there are lack of toxicology researches of 5-HMF and its metabolites in TCMIs, although the potential toxicity of 5-HMF and its metabolites has been reported. Moreover, the content of 5-HMF largely varies from TCMIs to TCMIs, and even in the same TCMIs from different factories. To ensure the clinical efficacy of TCMIs, it urgent to carry out the study of the toxicology of 5-HMF in TCMIs comprehensively and systematically, so as to set up a relatively uniform standard as well as to develop process quality control method.
