Key physical parameters of hawthorn leaf granules by stepwise regression analysis method.
10.19540/j.cnki.cjcmm.20170307.011
- Author:
Qie-Ying JIANG
1
;
Rong-Gui ZENG
2
;
Zhe LI
2
;
Juan LUO
2
;
Guo-Wei ZHAO
2
;
Dan LV
2
;
Zheng-Gen LIAO
2
Author Information
1. School of Continuing Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
2. Key Laboratory of Modern Preparation of Chinese Materia Medica, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
dissolution rate constant;
equilibrium dissolution quantity;
granule;
hawthorn leaves;
physical properties;
stepwise regression analysis method
- From:
China Journal of Chinese Materia Medica
2017;42(10):1894-1900
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of this study was to investigate the effect of key physical properties of hawthorn leaf granule on its dissolution behavior. Hawthorn leaves extract was utilized as a model drug. The extract was mixed with microcrystalline cellulose or starch with the same ratio by using different methods. Appropriate amount of lubricant and disintegrating agent was added into part of the mixed powder, and then the granules were prepared by using extrusion granulation and high shear granulation. The granules dissolution behavior was evaluated by using equilibrium dissolution quantity and dissolution rate constant of the hypericin as the indicators. Then the effect of physical properties on dissolution behavior was analyzed through the stepwise regression analysis method. The equilibrium dissolution quantity of hypericin and adsorption heat constant in hawthorn leaves were positively correlated with the monolayer adsorption capacity and negatively correlated with the moisture absorption rate constant. The dissolution rate constants were decreased with the increase of Hausner rate, monolayer adsorption capacity and adsorption heat constant, and were increased with the increase of Carr index and specific surface area. Adsorption heat constant, monolayer adsorption capacity, moisture absorption rate constant, Carr index and specific surface area were the key physical properties of hawthorn leaf granule to affect its dissolution behavior.
