Transcriptomics of therapeutic effect of Huangqi Liuyi decoction in treating type 2 diabetes.
10.19540/j.cnki.cjcmm.20170609.003
- Author:
Yue CHANG
1
;
Jiao XU
1
;
Song YAN
1
;
Zhen-Peng LIU
1
;
Wei-Chao REN
1
;
Kai-Xue ZHANG
1
;
Wei MA
1
;
Xiu-Bo LIU
1
Author Information
1. School of Pharmaceutical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
- Publication Type:Journal Article
- Keywords:
Huangqi Liuyi decoction;
KEGG enrichment analysis;
eggNOG analysis;
transcriptomics;
type 2 diabetes mellitus
- From:
China Journal of Chinese Materia Medica
2017;42(14):2760-2766
- CountryChina
- Language:Chinese
-
Abstract:
In this study, Illumina sequencing platform was applied in sequencing rat pancreas, counting expression of target points, analyzing expression differences among blank group, model group and Huangqi Liuyi decoction group and exploring the therapeutic effect and mechanism of Huangqi Liuyi decoction on type 2 diabetes mellitus. According to the result, 24.25% of these genes belonged to the unknown functional class, which was the largest classification unit according to the classification analysis of genes by eggNOG. The rest were classified as energy conversion, amino acid transport and metabolism, nucleotide transport and metabolism, carbohydrate transport and metabolism, coenzyme transport and metabolism, and lipid transport and metabolism, etc.Huangqi Liuyi decoction may play a therapeutic role in the treatment of type 2 diabetes mellitus through four metabolic pathways, namely environmental information processing, cellular process, organismal system and human diseases according to KEGG enrichment analysis. This study shows that, Huangqi Liuyi decoction can significantly improve the fasting blood glucose and glycosylated hemoglobin in type 2 diabetic rats.
