Oral absorption of asiatic acid nanoparticles modified with PEG.
10.19540/j.cnki.cjcmm.20170523.001
- Author:
Ya-Wen ZHANG
1
;
Li-Na YIN
1
;
Xia-Ying HUANG
1
;
Ze-Hua LIANG
2
;
Xiao-Xiao CHEN
2
;
Sheng-Hao WANG
1
Author Information
1. Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
2. College of Pharmaceutical Science, Zhejiang University of Trasditional Chinese Medicine, Hangzhou 310053, China.
- Publication Type:Journal Article
- Keywords:
PEG;
asiatic acid;
nanostructured lipid carrier;
oral absorption
- From:
China Journal of Chinese Materia Medica
2017;42(14):2784-2788
- CountryChina
- Language:Chinese
-
Abstract:
A solvent diffusion method was used to prepare pegylated asiatic acid (AA) loaded nanostructured lipid carriers (p-AA-NLC), and the ligated intestinal circulation model was established to observe the absorption and distribution in small intestine. The concentration of AA in bile after oral administration of p-AA-NLC was detected by HPLC in healthy SD rats to indirectly evaluate the oral absorption promoting effect of PEG-modified namoparticles. The results showed that the penetration of p-AA-NLC was enhanced significantly and the transport capacity was increased greatly in small intestinal after PEG modification. As compared with the normal nanoparticles (AA-NLC), the Cmax of the drug excretion was increased by 76%, the time to reach the peak (tmax ) was decreased and the elimination half-life t1/2 was doubled in the rats after oral administration of p-AA-NLC, and the AUC0→t was 1.5 times of the AA-NLC group, indicating that the oral bioavailability of AA-NLC was significantly improved by hydrophilic modification of PEG.
