Effect of fluidized bed technology on micromeritics properties of Leonurus Herba extract.
10.19540/j.cnki.cjcmm.20170503.001
- Author:
Yan DU
1
;
Qi-Zhi YI
2
;
Yao-Kun XIONG
3
;
Lan-Ping XU
1
Author Information
1. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China.
2. College of Mathematics & Information Science, Jiangxi Normal University, Nanchang 330022, China.
3. Key Laboratory for Modern Preparation of Traditional Chinese Medicine Under Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330011, China.
- Publication Type:Journal Article
- Keywords:
Leonurus Herba extract;
compression property;
fluidized;
hygroscopicity
- From:
China Journal of Chinese Materia Medica
2017;42(15):2977-2983
- CountryChina
- Language:Chinese
-
Abstract:
Based on different binders, the Leonurus Herba extract powders were fluidized and modified. The physical properties such as hygroscopicity, flowability, filling property and compression property were studied by various micromeritics methods before and after modification. The results showed that the physical properties of Leonurus Herba extract were close to those of microcrystalline cellulose, and its comprehensive flow index was between 61-75. Fluidization process can improve hygroscopicity, so the moisture absorption indexes of the samples were significantly lower than those of the original Leonurus Herba extract samples. With the plastic constant, compression ratio and yield stress, Heckel equation and Kawakita equation as the the investigation indicators, results showed that fluidization process based on binder water was superior to other methods in increasing the compressibility of the extracts. In low and medium pressure, the fluidized and modified extract can form the tablets with a certain strength. Fluidized transformation had a greater influence on the properties of original Leonurus Herba extracts, which was instructive to guide significance for the surface modification of pharmaceutical powders and provide the basis for the development of extract tablet.
