Intraventricular injection of 5,7-dihydroxytryptamine alters neuronal activity of neurons in the medial prefrontal cortex of rat.
- Author:
Ling-Ling FAN
1
;
Zhi-Hong HU
;
Yu-Dong ZHOU
;
Qian-Qian LI
;
Yan-Ru JIA
;
Jin-Feng WANG
;
Chun-Wei ZHAO
Author Information
1. Medical College, Henan University of Science and Technology, Luoyang 471003, China. emmafll@163.com.
- Publication Type:Journal Article
- MeSH:
5,7-Dihydroxytryptamine;
pharmacology;
Action Potentials;
Animals;
Dorsal Raphe Nucleus;
cytology;
Injections, Intraventricular;
Interneurons;
drug effects;
Prefrontal Cortex;
cytology;
Pyramidal Cells;
drug effects;
Rats;
Serotonin;
metabolism
- From:
Acta Physiologica Sinica
2014;66(6):667-674
- CountryChina
- Language:Chinese
-
Abstract:
The present study is aimed to investigated the firing activity of pyramidal neurons and interneurons in the medial prefrontal cortex (mPFC) in rats with bilateral intraventricular injection of 5,7-dihydroxytryptamine (5,7-DHT) by using in vivo extracellular recording. The results showed that the injection of 5,7-DHT reduced the 5-hydroxytryptamine (5-HT) levels in the mPFC and dorsal raphe nucleus in the rats. The firing rate of mPFC pyramidal neurons in rats with 5,7-DHT injection was significantly higher than that of normal rats, and the firing pattern of these neurons also changed significantly towards a more burst-firing, while the injection decreased the firing rate of mPFC interneurons and changed the firing pattern of the interneurons towards a more irregular. These results indicate that the lesions of the serotonergic neurons lead to the changes in the firing activity of mPFC pyramidal neurons and interneurons, suggesting that serotonergic system plays an important role in the regulation of the neuronal activity in the mPFC.
