Wavelet packet extraction and entropy analysis of telemetry EEG from the prelimbic cortex of medial prefrontal cortex in morphine-induced CPP rats.
- Author:
Yu BAI
1
,
2
;
Jia-Ming BAI
;
Jing LI
;
Min LI
;
Ran YU
;
Qun-Wan PAN
Author Information
1. Department of Computer
2. Department of Physiology, Wannan Medical College, Wuhu 241000, China. panqunw@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Conditioning (Psychology);
Drug-Seeking Behavior;
Electroencephalography;
Entropy;
Morphine;
pharmacology;
Prefrontal Cortex;
drug effects;
Rats;
Telemetry;
Wavelet Analysis
- From:
Acta Physiologica Sinica
2014;66(6):675-682
- CountryChina
- Language:Chinese
-
Abstract:
The purpose of the present study is to analyze the relationship between the telemetry electroencephalogram (EEG) changes of the prelimbic (PL) cortex and the drug-seeking behavior of morphine-induced conditioned place preference (CPP) rats by using the wavelet packet extraction and entropy measurement. The recording electrode was stereotactically implanted into the PL cortex of rats. The animals were then divided randomly into operation-only control and morphine-induced CPP groups, respectively. A CPP video system in combination with an EEG wireless telemetry device was used for recording EEG of PL cortex when the rats shuttled between black-white or white-black chambers. The telemetry recorded EEGs were analyzed by wavelet packet extraction, Welch power spectrum estimate, normalized amplitude and Shannon entropy algorithm. The results showed that, compared with operation-only control group, the left PL cortex's EEG of morphine-induced CPP group during black-white chamber shuttling exhibited the following changes: (1) the amplitude of average EEG for each frequency bands extracted by wavelet packet was reduced; (2) the Welch power intensity was increased significantly in 10-50 Hz EEG band (P < 0.01 or P < 0.05); (3) Shannon entropy was increased in β, γ₁, and γ₂waves of the EEG (P < 0.01 or P < 0.05); and (4) the average information entropy was reduced (P < 0.01). The results suggest that above mentioned EEG changes in morphine-induced CPP group rat may be related to animals' drug-seeking motivation and behavior launching.
