Signaling molecules and pathways involved in maintaining the quiescence of primordial follicles.
- Author:
Liao-Liao HU
1
;
Cheng XIANG
1
;
Li-Ping ZHENG
2
Author Information
1. Department of Medical Experimental Teaching, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
2. Department of Medical Experimental Teaching, Jiangxi Medical College, Nanchang University, Nanchang 330031, China. zhengliping@ncu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Female;
Humans;
Ovarian Follicle;
physiology;
Signal Transduction
- From:
Acta Physiologica Sinica
2015;67(1):59-64
- CountryChina
- Language:Chinese
-
Abstract:
Reproductive lifespan in female mammals is related to the size of primordial follicles pool, which relies on the balance between activated and quiescent primordial follicles. Therefore, the molecular mechanisms of recruiting and maintaining quiescence of primordial follicles have become hot research topics recently. Multiple studies have shown that genetic mutations, local ovarian autocrine and paracrine factors, proto-oncogene and tumor-suppressor genes are involved in the maintenance of balance between quiescent and activated primordial follicles. In the present review, we summarize recent research progress of the important signaling molecules and pathways that maintain the quiescence of primordial follicles.
