Pure red cell aplasia following major ABO-incompatible allogeneic hematopoietic stem cell transplantation.
- Author:
Xiao-jun HUANG
1
;
Dai-hong LIU
;
Lan-ping XU
;
Wei HAN
;
Qian JIANG
;
Yu-hong CHEN
;
Yao-chen ZHANG
;
Kai-yan LIU
;
Li BAO
;
Dao-pei LU
Author Information
- Publication Type:Journal Article
- MeSH: ABO Blood-Group System; immunology; Blood Group Incompatibility; Hematopoietic Stem Cell Transplantation; adverse effects; methods; Humans; Postoperative Complications; etiology; therapy; Prognosis; Red-Cell Aplasia, Pure; etiology; therapy; Retrospective Studies; Risk Factors
- From: Chinese Journal of Hematology 2005;26(9):548-550
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo study clinical characteristics and outcome of pure red cell aplasia (PRCA) following major ABO-incompatible allogeneic hematopoietic stem cell transplantation (allo-HSCT).
METHODSVariables including sex, age, stem cell source, granulocyte engraftment time, blood transfusion and isoagglutinin type against donor RBC were analyzed to identify risk factors for the development of PRCA.
RESULTSTwelve of 100 patients received major ABO-incompatible allo-HSCT developed PRCA, with out any effect on incidence of aGVHD and CMV infection. ABO blood groups of recipient/donor pairs of these twelve PRCA patients were O/A in nine, B/A in one and O/B in two. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than those with anti-B (10/49 vs 2/49). Median duration to the recovery of erythropoiesis tended to be longer in patients with PRCA (PRCA vs non-PRCA, 203.5 vs. 76 days, P < 0.05 ). Median durations to the disappearance of incompatible isoagglutinins tended to be longer in patients with PRCA (PRCA vs. non-PRCA, 150.5 vs. 60 days,P <0.05) and in those with anti-A isoagglutinins (anti-A vs anti-B, 90 vs 55 days, P < 0.05).
CONCLUSIONABO blood group of O/A in recipient/donor pair was the only high risk factor for PRCA after major ABO-incompatible allo-HSCT.
