Clinicopathological and biological features of breast cancer in young females and their relationship with prognosis.
- Author:
Jie MENG
1
;
Rong-gang LANG
;
Yu FAN
;
Li FU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Biomarkers, Tumor; analysis; Breast Neoplasms; metabolism; mortality; pathology; Carcinoma, Ductal, Breast; metabolism; pathology; Female; Follow-Up Studies; Humans; Immunohistochemistry; statistics & numerical data; Ki-67 Antigen; analysis; Lymphatic Metastasis; Multivariate Analysis; Prognosis; Proportional Hazards Models; Receptor, ErbB-2; analysis; Receptors, Androgen; analysis; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Retrospective Studies; Survival Analysis; Survival Rate; Tumor Suppressor Protein p53; analysis
- From: Chinese Journal of Oncology 2007;29(4):284-288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between clinicopathological and biological characteristics and prognosis in young females with breast cancer.
METHODSThe clinicopathological data of 99 young patients (< or =35years) with primary breast cancer were analyzed retrospectively. All the 99 patients were followed up for 5 years. The histological specimens were reviewed. The expression of ER, PR, AR, c-erbB2, ki67, p53 and BRCA1 were assessed by immunohistochemistry in 63 carcinomas.
RESULTSThe lymph node involvement, 5-year metastasis and 5-year survival rate were 59.6% (59/99), 28.0% (26/ 93) and 72.7% (72/99), respectively. The univariate analysis showed that the survival was related to lymphatic vessel invasion, fat involvement, node-positive status, EIC, AR and c-erbB2 expression. The COX multivariate analysis identified that only node-positive status, AR negativity and c-erbB2 overexpression were independent prognostic factors.
CONCLUSIONOur data demonstrated that the lymph node status and c-erbB2 expression are strong prognostic factors in young patients with breast cancer. AR may be an adjuvant prognostic factor. The therapeutic measurement could not benefit the outcome radically.
