Factors influencing the long-term survival in pancreatic carcinoma patients after radical resection.
- Author:
Wei-jian ZHANG
1
;
Shao-liang HAN
;
Fei-zhao JIANG
;
Heng-liang ZHU
;
Bai-liang YE
;
Qing-hong KE
;
Yao FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; pathology; surgery; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Pancreatectomy; Pancreatic Neoplasms; pathology; surgery; Proportional Hazards Models; Retrospective Studies; Survival Rate; Tumor Burden; Young Adult
- From: Chinese Journal of Oncology 2008;30(11):870-872
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the factors influencing the long-term survival of pancreatic carcinoma patients after radical resection.
METHODSThe data of 184 pancreatic carcinoma patients with radical resection were analyzed retrospectively. Analysis of the prognostic factors influencing the long-term survival was performed using Cox proportional hazard regression model.
RESULTSThe overall 1-, 3- and 5-year survival rates in this group were 61.7%, 29.0% and 14.3%, respectively. They were 78.0%, 38.4% and 25.7%, respectively, for the patients with a tumor < 3 cm in diameter, significantly better than those with a tumor >or= 3 cm (52.8%, 22.7% and 7.2%, respectively, P < 0.05). Moreover, the 1-, 3- and 5-year survival rates were 67.6%, 30.5% and 17.4%, respectively, in the patients without lymph node involvement, much longer than that in those with lymph node metastasis (37.1%, 20.6% and 0, respectively, P < 0.05). Multivariate analysis by Cox proportional hazard regression model revealed that the tumor size (P < 0.05) and lymph node metastasis (P < 0.01) significantly influenced the long-term survival of the patients.
CONCLUSIONTumor size and lymph node metastasis are significant factors influencing the long-term survival of pancreatic carcinoma patients with radical resection. Therefore, early diagnosis and radical resection are the key points to improve treatment outcome.
