Clinicopathological characteristics and prognostic factors of breast cancer with estrogen- and progesterone-receptor negative and HER-2 overexpression.
- Author:
Ying FAN
1
;
Yin GUAN
;
Wei-Hong ZHAO
;
Qing LI
;
Bing-He XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; drug therapy; metabolism; pathology; surgery; Carcinoma in Situ; drug therapy; metabolism; pathology; surgery; Carcinoma, Ductal, Breast; drug therapy; metabolism; pathology; surgery; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Mastectomy; methods; Middle Aged; Neoplasm Staging; Proportional Hazards Models; Receptor, ErbB-2; metabolism; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Retrospective Studies; Survival Rate; Tumor Burden; Young Adult
- From: Chinese Journal of Oncology 2008;30(12):917-920
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinicopathological characteristics and prognosis of breast cancer with estrogen- and progesterone-receptor negative (ER-/PR-) and HER-2 overexpression (HER+++) in a Chinese population.
METHODSThe data of patients with ER-/PR- and HER+++ breast cancer treated in our hospital from March 1999 to December 2004 were retrospectively reviewed. The influence of clinicopathological characteristics and molecular markers on the survival was analyzed.
RESULTSA total of 111 breast cancer patients with ER and PR negative but HER+++ were identified, accounting for 4.9% of all the breast cancer patients treated during the same period. There were 25 cases (22.5%) in stage I, 44 (39.6%) in stage II and 36 (32.4%) in stage III, respectively, with a median age of 49 years. Axillary lymph node metastasis was found in 54 cases. The 5-year disease free survival (DFS) and overall survival rates (OS) were 70.7% and 73.1%, respectively. Univariate analysis showed that lymph node status, primary tumor size and pathological stage were prognosis-related factors influencing the DFS and OS. However, by multivariate analysis, only primary tumor size and lymph node status were independent factors influencing survival.
CONCLUSIONThe breast cancer with estrogen- and progesterone-receptor negative but HER-2 overexpression is a particular subtype of breast cancers, with unfavorable clinicopathological characteristics and poor survival. Lymph node status and primary tumor size are two independent prognostic factors.
