Expression of THY1 gene in epithelial ovarian cancer.
- Author:
Li-qin ZENG
1
;
Zhi-lan PENG
;
Zhen-ling DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Cystadenocarcinoma, Serous; metabolism; pathology; Cystadenoma, Serous; metabolism; pathology; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; metabolism; pathology; Thy-1 Antigens; metabolism; Young Adult
- From: Chinese Journal of Oncology 2009;31(2):118-120
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expession of THY1 in ovarian serous cystadenocarcinoma tissues.
METHODSImmunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53). The correlation of THY1 expression with clinicopathological parameters was statistically analyzed.
RESULTSThe positive expression rates of THY1 protein in normal ovaries, ovarian serous cystadenomas and ovarian serous cystadenocarcinomas were 60.0% (15/25), 72.0% (18/25) and 34.0% (18/53), respectively. The values of IOD of THY1 protein expression were 288,449.2 +/- 60,087.3, 271,655.6 +/- 66,588.7 and 252,087.6 +/- 45,559.4, respectively. The expression of THY1 protein was significantly down-regulated in ovarian serous cystadenocarcinoma tissues compared with that in normal ovarian tissues and ovarian serous cystadenoma tissues (P < 0.05). THY1 expression was negatively correlated with surgical-pathological staging, histological differentiation and lymph node involvement (P < 0.05).
CONCLUSIONThe decreased level of THY1 expression may be related with the occurrence and development of ovarian serous cystadenocarcinoma.
