Value of 18F-FDG and 11C-MET PET-CT in differentiation of brain ringlike-enhanced neoplastic and non-neoplastic lesions on MRI imaging.
- Author:
Li CAI
1
;
Shuo GAO
;
Da-cheng LI
;
Yan-sheng LI
;
Qiu-song CHEN
;
Xi-ling XING
Author Information
- Publication Type:Journal Article
- MeSH: Acetates; Adolescent; Adult; Aged; Brain Abscess; diagnosis; Brain Neoplasms; diagnosis; pathology; secondary; Carbon; Carbon Radioisotopes; Child; Craniopharyngioma; diagnosis; pathology; secondary; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Glioblastoma; diagnosis; pathology; secondary; Humans; Lung Neoplasms; diagnosis; pathology; Magnetic Resonance Imaging; Male; Middle Aged; Pituitary Neoplasms; diagnosis; pathology; secondary; Positron-Emission Tomography; methods; Radiopharmaceuticals; Sensitivity and Specificity; Young Adult
- From: Chinese Journal of Oncology 2009;31(2):134-138
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of (18)F-FDG and (11)C-MET PET-CT scan in differentiation of brain ringlike-enhanced lesions on MRI imaging.
METHODSForty-one brain ringlike-enhanced lesions on MRI imaging including 30 brain tumors and 11 non-neoplastic lesions confirmed pathologically or clinically underwent (18)F-FDG and (11)C-MET PET-CT brain scan. Among them, 15 patients who were suspected to have brain metastasis received body scan by (18)F-FDG PET-CT. Both images were analyzed visually and semi-quantitatively.
RESULTSVisual analysis: for brain tumors the diagnostic sensitivity, specificity and accuracy of (18)F-FDG PET-CT was 53.3%, 72.7%, 58.5%, versus 96.7%, 90.9%, 95.1% of (11)C-MET PET-CT, respectively. All the primary foci in 9 patients with brain metastases were detected by body (18)F-FDG PET-CT scan. Semiquantitative analysis: There was a significant difference in the uptake between highly differentiated malignant and poorly differentiated tumors as well as non-neoplastic lesions for both tracers (P < 0.01), while between low-grade malignant tumors and non-neoplasm lesions, there was a difference in uptake only by (11)C-MET (P < 0.01). No significant difference between the uptakes in brain metastasis and glioblastomas was found by both tracers (P > 0.05).
CONCLUSIONBoth (18)F-FDG and (11)C-MET PET-CT are useful in differentiation of brain ringlike-enhanced lesions on MRI imaging. (11)C-MET PET-CT is more helpful than (18)F-FDG PET-CT in differential diagnosis of low-grade neoplastic from non-neoplastic lesions. Combination of (18)F-FDG and (11)C-MET PET-CT scans can improve the accuracy of differential diagnosis for brain ringlike-enhanced lesions on MRI imaging.
