Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity.
- Author:
Qiao ZHONG
1
;
Shi-he SHAO
;
Lei-lei CUI
;
Run-hong MU
;
Xiao-li JU
;
Su-rong DONG
Author Information
- Publication Type:Journal Article
- MeSH: Bacterial Proteins; metabolism; DNA-Binding Proteins; Gene Transfer, Horizontal; Helicobacter pylori; genetics; metabolism; pathogenicity; Multigene Family
- From: Chinese Medical Journal 2007;120(23):2138-2142
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo review the research progress on Type IV secretion system (T4SS) in Helicobacter pylori.
DATA SOURCESThe data used in this review were identified by searching of PUBMED (1995 - 2007) online resources using the key terms 'Type IV secretion system' and 'Helicobacter pylori'.
STUDY SELECTIONMainly original articles and critical reviews written by major pioneer investigators of this field were selected.
RESULTSThe research progress on T4SS in Helicobacter pylori was summarized. The structure and function was discussed.
CONCLUSIONST4SS is not only involved in toxin secretion and injection of virulence factors into eukaryotic host target cells, but also involved in horizontal DNA transfer to other bacteria and eukaryotic cells, through DNA uptake from or release into the extracellular milieu. It provides a new insight into the pathogenicity of Helicobacter pylori and a novel target for antimicrobials development. However, many challenges remain for us in understanding the biological role of T4SS in Helicobacter pylori.
