Primitive study of the cell lineage and Epstein-Barr virus infection in so called malignant histiocytosis with tissue microarray technique.
- Author:
Changli LU
1
;
Weiping LIU
;
Jia GUO
;
Gandi LI
;
Fengyuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Epstein-Barr Virus Infections; pathology; Female; Histiocytic Sarcoma; pathology; virology; Humans; Immunohistochemistry; In Situ Hybridization; Lymphoma, T-Cell; immunology; Male; Polymerase Chain Reaction
- From: Chinese Journal of Pathology 2002;31(6):497-501
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the cell lineage and Epstein-Barr virus infection in previously diagnosed cases of malignant histiocytosis (MH) with tissue microarray technique.
METHODSUsing tissue-chips, immunohistochemical staining, in situ hybridization and PCR to analyze 5 autopsy cases of MH.
RESULTS(1) In all 5 cases, positive reactions of CD45RO, CD3 epsilon, TIA-1, Granzyme B were detected in the neoplastic cells, whereas negative reactions were found with CD30, CD20, CD56. (2) All cases revealed EBER1/2 positivity in neoplastic cells.
CONCLUSIONPreviously diagnosed malignant histiocytosis is an EBV-associated aggressive NK/T cell lymphoma.
