Tissue transglutaminase protein expression in human brain tumors.
- Author:
Rui WANG
1
;
Wei-zhong YANG
;
Song-sheng SHI
;
Fa-duan YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Apoptosis; Astrocytoma; enzymology; pathology; Brain Neoplasms; enzymology; pathology; Child; Endothelial Cells; enzymology; Female; GTP-Binding Proteins; biosynthesis; Humans; Immunohistochemistry; Male; Middle Aged; Oligodendroglioma; enzymology; pathology; Transglutaminases; biosynthesis
- From: Chinese Journal of Pathology 2003;32(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate expression of tissue transglutaminase (tTG) protein and its role in carcinogenesis of brain tumors.
METHODStTG protein was detected by immunohistochemical method in 62 astrocytomas, 18 oligodendrogliomas, 30 benign meningiomas, 30 pituitary adenomas and 10 normal brain tissues.
RESULTS(1) In brain tumors, tTG protein expression was heterogeneous locating in tumor and endothelial cells. (2) Immunoreactivity of tTG protein was significantly different between different grades of astrocytomas. (3) Expression intensity of tTG protein in glioma was higher than that in benign brain tumors. (4) Strong expression of tTG protein in tumor cell was obtained around the necrosis foci and apoptotic cells in astrocytomas.
CONCLUSIONStTG protein expression contributed to tumor malignant progression in malignant brain tumors.
