Primary gastric endocrine tumors.
- Author:
Shang-mei LIU
1
;
Xiu-yun LIU
;
Shuang-mei ZOU
;
Guo-lian WEI
;
Yun-tian SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoembryonic Antigen; metabolism; Carcinoid Tumor; metabolism; pathology; Carcinoma, Small Cell; metabolism; pathology; Female; Gastrins; metabolism; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neuroendocrine Tumors; metabolism; pathology; Phosphopyruvate Hydratase; metabolism; Prognosis; Stomach Neoplasms; metabolism; pathology
- From: Chinese Journal of Pathology 2003;32(1):38-42
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathological features of gastric neuroendocrine tumors.
METHODSTwenty cases were reviewed. The specimens were formalin-fixed, paraffin-embedded and immunostained by S-P method.
RESULTSAmong the twenty cases, one case was carcinoid, three were malignant carcinoids, six had small cell carcinomas and ten had mixed extocrine--endocrine carcinomas. Immunohistological examination of tumor cells found 80% positive for S-100, NSE (85%), CgA (50%), SY (50%), gastrin (30%), serotonin (65%), AE1/AE3 (50%), and CEA (80%).
CONCLUSIONSIn the WHO classification, there are five histological types in endocrine tumors of gastrointestinal tract. They are carcinoid, malignant carcinoid, small cell carcinoma, mixed exocrine--endocrine carcinoma and tumor-like lesions. But some cases in our paper were so different that they could not be classified. The gastric endocrine tumors are different from intestinal endocrine tumors and in classification, treatment and prognosis.
