Study on the origin and differentiation of gastrointestinal stromal tumors.
- Author:
Ying-yong HOU
1
;
Xiong-zeng ZHU
;
Jian WANG
;
Yun-shan TAN
;
Meng-hong SUN
;
Xiang DU
;
Da-ren SHI
;
null
Author Information
- Publication Type:Journal Article
- MeSH: Cell Differentiation; Gastrointestinal Stromal Tumors; chemistry; ultrastructure; Golgi Apparatus; ultrastructure; Humans; Immunohistochemistry; Microscopy, Electron; Proto-Oncogene Proteins c-kit; analysis; S100 Proteins; analysis; Stromal Cells; chemistry; ultrastructure; Ubiquitin Thiolesterase; analysis
- From: Chinese Journal of Pathology 2003;32(2):106-110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the origin and differentiation of gastrointestinal stromal tumors (GISTs).
METHODSImmunohistochemistry staining and electron microscopy were adopted.
RESULTSIn 212 cases of primary GISTs, the positive rates of CD117, CD34, alpha-SMA, MSA, desmin, S-100, PGP9.5 were 96.7%, 77.3%, 19.3%, 15.6%, 1.9%, 16.3%, and 12.3% respectively. Among them, GISTs showed a diffuse and strong positivity for CD117. Electron microscopy of tumor cells demonstrated numerous mitochondria, prominent perinuclear Golgi complex, smooth and rough endoplasmical reticulum and intermediate filaments. Irregular caveolae, dense plaque, incontinuous basal lamina were observed occasionally. Cytoplasmic processes were often observed accompanying with local adhesion present between the processes or between the processes and the cell membrane.
CONCLUSIONSData from both immunophenotype and electron microscopy suggest that GIST might originate from the mesenchymal cells, differentiating to be ICC afterwards, and possessing myoid characteristics in various extent.
