Clinicopathological and immunohistochemical analysis of gastrointestinal, urinary and perineal stromal tumors.
- Author:
Gong-huang YU
1
;
Xing-hao NI
;
Feng QIAN
;
Li-hong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Actins; analysis; Adult; Aged; Aged, 80 and over; Antigens, CD34; analysis; Biomarkers, Tumor; analysis; Female; Gastrointestinal Stromal Tumors; chemistry; pathology; Humans; Immunohistochemistry; Leiomyoma; chemistry; pathology; Leiomyosarcoma; chemistry; pathology; Male; Middle Aged; Neurilemmoma; chemistry; pathology; Pelvic Neoplasms; chemistry; pathology; Perineum; Proto-Oncogene Proteins c-kit; analysis; Retrospective Studies; S100 Proteins; analysis; Urologic Neoplasms; chemistry; pathology
- From: Chinese Journal of Pathology 2003;32(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the histogenesis and pathological characteristics of gastrointestinal stromal tumors (GIST) and GIST type stromal tumor (ST) beyond the gastrointestinal tract.
METHODSA retrospective study was carried out on leiomyoma, leiomyosarcoma and neurilemoma (46 cases in gastrointestinal tract and l3 cases in urinary tract and perineal area). 4 antibodies (CD117, CD34, SMA, S-100) were used for immunohistochemical staining.
RESULTSAmong 45 cases of GIST, the positive rate of CD117 and CD34 was 93.3% and 88.9% respectively. Among 12 cases of GIST type ST beyond the gastrointestinal tract, the positive rate of CD117 and CD34 was 83.3% and 75.0% respectively. In 2 cases (1 in gastrointestinal tract) of leiomyomas, both CD117 and CD 34 were negative in tumor cells, while SMA was extensively positive.
CONCLUSIONSCD117 and CD34 positivity are the most valuable factors in diagnosing ST. Both GIST and GIST type ST beyond the gastrointestinal tract are considered originating from a proto-interstitial stem cell with disoriented differentiation.
