Effect of S-bioallethrin on human lymphocyte.
- Author:
Yue LIU
1
;
Li-Yan LIANG
;
Wen-Li MA
;
Wen-Ling ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Allethrin; pharmacology; Apoptosis; drug effects; Flow Cytometry; Gene Expression Profiling; Humans; Insecticides; pharmacology; Lymphocytes; drug effects; metabolism; ultrastructure; Microscopy, Electron; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction
- From: Journal of Southern Medical University 2006;26(3):321-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of the S-bioallethrin on human lymphocytes by microarray technique.
METHODSThe changes of normal human lymphocytes treated with S-bioallethrin were examined with light microscope, flow cytometry, electron microscope, DNA ladder and microarray techniques.
RESULTSMorphological study showed that the lymphocytes underwent apoptosis after S-bioallethrin exposure, which as further confirmed by the expression changes of 346 genes.
CONCLUSIONS-bioallethrin can induce apoptosis of normal human lymphocytes and changes in their gene expression profiles.
