Clinical efficacy of low-dose oral theophylline for treating mild asthma.
- Author:
Shao-dan HUANG
1
;
Jun YANG
;
Shi-ye ZHANG
;
Li-qi TIAN
;
Qiao-hong PAN
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Adult; Asthma; drug therapy; immunology; physiopathology; Bronchodilator Agents; administration & dosage; therapeutic use; Female; Humans; Male; Middle Aged; Respiratory Function Tests; T-Lymphocyte Subsets; drug effects; immunology; Theophylline; administration & dosage; therapeutic use; Treatment Outcome
- From: Journal of Southern Medical University 2006;26(3):325-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the role of theophylline in relieving airway symptoms and inflammation in patients with mild asthma.
METHODSFifty-six patients with mild asthma were randomly divided into treatment group (n=41) receiving oral theophylline at daily dose of 4 to 6 mg/kg for 16 weeks and control group (15 cases) without medication other than beta2 antagonist, which was administered when necessary in both groups. Peripheral blood T-lymphocyte subsets (CD3(+), CD4(+), and CD8(+)) and pulmonary function (PEF(am) and PD(20)) before and at 8 and 16 weeks during treatment were measured.
RESULTSSignificant difference was observed in CD3+ and CD4(+) T-lymphocyte subsets after medication with theophylline (P<0.05) in the patients, and PEF(am) and PD(20) were also significantly different from those of the control group (P<0.05). Theophylline significantly improved the clinical symptom scores (P<0.05) and decreased the asthma attacks.
CONCLUSIONLow-dose oral theophylline may significantly relieving airway inflammation in patients with mild asthma.
