Changes in P-selectin expression after brain injury in rats.
- Author:
Rong-jun ZHANG
1
;
Chao YOU
;
Bo-wen CAI
;
Min HE
;
Yong-bo YANG
;
Zhan LIU
;
Qing-fang JIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Chemistry; Brain Injuries; etiology; metabolism; pathology; Female; Immunohistochemistry; P-Selectin; biosynthesis; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Journal of Southern Medical University 2006;26(3):348-351
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between expression thange of P-selectin after brain injury and secondary brain damage.
METHODSSixty SD rats were randomized into 3 equal groups, namely the control group, mild injury group and severe injury group and animal models of brain injury were established in SD rats according to the method of Feeney. P-selectin expression in the brain tissues were determined at 6 h and l, 3, and 7 days following brain injury (n=5 for each time point). Imaging analysis was performed using computerized imaging technique.
RESULTSP-selectin expression and neutrophil infiltration in the brain tissues increased significantly 6 h after brain injury (P<0.05), reaching the peak level at postoperative 24 h and then gradually decreased.
CONCLUSIONP-selectin expression and neutrophil infiltration increase significantly following brain injury, and the time course and distribution of P-selectin expression are consistent with the secondary damage of the brain, strongly suggesting the involvement of P-selectin upregulation in the secondary insult after brain injury.
