Evaluation of cerebral vasospasm resulting from subarachnoid hemorrhage with 1H-magnetic resonance spectroscopy.
- Author:
Wei QUAN
1
;
Tie-lin LI
;
Guang-zhong CHEN
;
Xiao-dan JIANG
;
Ru-xiang XU
;
Yi-quan KE
;
Chuan-zhi DUAN
;
Jian-ping LÜ
;
Hao ZHANG
;
Wei XIE
;
Wen-jun ZHONG
;
Ying-dong CHEN
;
Fan-fan CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aspartic Acid; analogs & derivatives; metabolism; Choline; metabolism; Creatine; metabolism; Dogs; Female; Magnetic Resonance Spectroscopy; methods; Male; Protons; Subarachnoid Hemorrhage; complications; Time Factors; Vasospasm, Intracranial; diagnosis; etiology; metabolism
- From: Journal of Southern Medical University 2006;26(3):352-354
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the value of (1)H-magnetic resonance spectroscopy ((1)H-MRS) in evaluating cerebral vasospasm resulting from subarachnoid hemorrhage (SAH).
METHODSSix dogs were subjected to autologous non-heparinized blood injection via cisternal puncture twice at one-day interval to establish models of SAH, and another 6 received injections with normal saline in an identical manner. (1)H-MRS scan was performed on the 3rd, 7th and 14th days after the injections to measure the changes of N-acetylaspartate (NAA), creatine (Cr) and choline (Cho). After the (1)H-MRS scan, all the dogs underwent brain digital subtraction angiography (DSA) for determining the basilar artery diameter.
RESULTSDSA results on day 3 presented development of obvious vasospasm of the basilar artery, which was most evident on day 7 and recovered obviously on day 14. (1)H-MRS results demonstrated obvious changes of NAA, Cho and Cr on days 3 and 7 in SAH model group, and NAA declined to the lowest level on day 3 followed by gradual ascending till reaching the normal level on day 14. Cho decreased slightly on day 3, then increased and reached the peak level on day 7 and then decreased. Cr rose steadily from day 3 to 14, but since day 7, the rise slowed down obviously and Cr maintain a level not significantly different from that on day 14 (P>0.05). The functional results of (1)H-MRS were consistent with the DSA results.
CONCLUSION(1)H-MRS can be used to monitor the development of cerebral vasospasm resulting from SAH as a good evaluation method for functional imaging.