Relationship between serum interleukin-10 and insulin resistance in metabolic syndrome.
- Author:
Jian-hong YE
1
;
Zhi-zhen LI
;
Yan LI
;
Feng LI
;
Li YAN
;
Hua CHENG
;
Zu-zhi FU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Enzyme-Linked Immunosorbent Assay; Female; Glucose Clamp Technique; Humans; Insulin Resistance; Interleukin-10; blood; Male; Metabolic Syndrome; blood; Middle Aged
- From: Journal of Southern Medical University 2006;26(4):428-430
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between serum interleukin-10 (IL-10) level and insulin resistance (IR) in patients with metabolic syndrome (MS).
METHODSEighteen MS subjects and 18 age-matched normal subjects were enrolled. IR was evaluated by hyperinsulinemic-euglycemic clamp technique and serum IL-10 level measured by ELISA. Pearson's correlation analysis was used to investigate the relationship between serum IL-10 level and IR.
RESULTSSerum IL-10 levels were significantly higher in patients with MS than in the controls [1.3 (0.8/3.1) pg/ml vs 2.4 (1.1/4.5) pg/ml, P<0.05], and glucose metabolic rate (M value) derived from hyperinsulinemic-euglycemic clamp technique was lower in MS subjects than in controls [(5.76+/-1.81) mg/kg.min vs (8.39+/-1.25) mg/kg.min], P<0.05]. Serum IL-10 levels showed a positive correlation with M value (P<0.05).
CONCLUSIONPatients with MS have greater IR and lower serum IL-10 levels than normal subjects, and lowered IL-10 levels might be involved in the pathogenesis of IR in MS.
