Cancer Stem Cells in Brain Tumors and Their Lineage Hierarchy.
- Author:
Doo Sik KONG
1
Author Information
1. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kds026@skku.edu
- Publication Type:Review
- Keywords:
Cell of origin;
Cancer stem cell;
Lineage hierarchy
- MeSH:
Brain;
Brain Neoplasms;
Glioma;
Neoplastic Stem Cells;
Population Characteristics;
Prognosis
- From:International Journal of Stem Cells
2012;5(1):12-15
- CountryRepublic of Korea
- Language:English
-
Abstract:
Despite recent advances in the development of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. The chemo-resistance of this tumor is attributed to tumor heterogeneity. To explain this unique chemo- resistance, the concept of cancer stem cells has been evoked. Cancer stem cells, a subpopulation of whole tumor cells, are now regarded as candidate therapeutic targets. Here, the author reviews and discusses the cancer stem cell concept.
