Effect of perioperative continuous epidural morphine administration on plasma D-dimer in patients undergoing total hip replacement.
- Author:
Gang WANG
1
;
Yi SUN
;
Gang-jian LUO
;
Pai-chong LIN
;
Pei-qing LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Arthroplasty, Replacement, Hip; Female; Fibrin Fibrinogen Degradation Products; metabolism; Humans; Injections, Epidural; Interleukin-6; blood; Male; Middle Aged; Morphine; administration & dosage; Perioperative Care; Postoperative Period
- From: Journal of Southern Medical University 2006;26(4):523-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of perioperative continuous epidural morphine administration on plasma D-dimer level in patients undergoing total hip replacement.
METHODSForty ASA I-II patients undergoing total hip replacement under epidural anesthesia were randomized into two groups. In one group, the patients were given epidural administration of morphine 15 min before operation at 4 mg (in 10 ml normal saline) and for 48 h after the operation at 80 microg/h, while those in the other group received epidural injection of the same amount of normal saline before operation and 0.15% ropivacaine 2.0 ml/h for 48 h in the same manner after operation. Blood samples were taken before anesthesia (T(0)), at the end of operation (T(1)), and 24 h and 48 h after operation (T(2) and T(3)) for determination of plasma IL-6 and D-dimer levels.
RESULTSIn both groups plasma IL-6 and D-dimer levels showed significant increase at T(1), T(2) and T(3) in comparison with those at T(0), and their levels were significantly lower in morphine group than in ropivacaine group at T(1), T(2) and T(3).
CONCLUSIONEpidural morphine can lower plasma IL-6 and D-dimer levels and correct blood hypercoagulability in patients undergoing total hip replacement.
