Effect of Shenkangwan on mesangial cell NO and TGF-beta1 excretion in rats with early diabetic nephropathy.
- Author:
Guo-bao CHEN
1
;
Lian-bo WEI
;
Wei XIAO
;
Hai-bo LONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Experimental; drug therapy; metabolism; Diabetic Nephropathies; drug therapy; metabolism; Drugs, Chinese Herbal; therapeutic use; Glomerular Mesangium; metabolism; pathology; Male; Nitric Oxide; biosynthesis; Rats; Rats, Wistar; Transforming Growth Factor beta; biosynthesis
- From: Journal of Southern Medical University 2006;26(4):526-528
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the mechanism of Shenkangwan (SKW) in treating early diabetic nephropathy (DN).
METHODSThe effect of SKW on NO and transforming growth factor (TGF)-beta(1) production by the mesangial cells (MCs) of rats with early diabetic nephropathy was evaluated with serum pharmacological method.
RESULTSCompared with normal serum, the SKW-containing serum dose- and time-dependently inhibited TGF-beta(1) excretion and increased NO production in the MCs of rats with early DN (P<0.05 and P<0.01, respectively).
CONCLUSIONThe therapeutic effect of SKW on early DN may rely on the balance modulation of cytokine network by increasing NO production and decreasing TGF-beta(1) excretion to prevent cytokine-induced damage of the MCs.
