Stimulation of Chondrogenic Differentiation of Mesenchymal Stem Cells.
- Author:
Da Ae YU
1
;
Jin HAN
;
Byung Soo KIM
Author Information
1. School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea. byungskim@snu.ac.kr
- Publication Type:Review
- Keywords:
Mesenchymal stem cell;
Chondrogenesis;
Growth factor;
Cellular interaction;
Biomaterial
- MeSH:
Biocompatible Materials;
Cartilage;
Cartilage, Articular;
Cell Communication;
Cell Death;
Chondrocytes;
Chondrogenesis;
Intercellular Signaling Peptides and Proteins;
Mesenchymal Stromal Cells
- From:International Journal of Stem Cells
2012;5(1):16-22
- CountryRepublic of Korea
- Language:English
-
Abstract:
The methods for cartilage repair have been studied so far, yet many of them seem to have limitations due to the low regenerative capacity of articular cartilage. Mesenchymal stem cell (MSC) has been suggested as an alternative solution to remedy this challenging problem. MSCs, which have extensive differentiation capacity, can be induced to differentiate into chondrocytes under specific conditions. Particularly, this review focused on the effects of growth factors, cell-to-cell interactions and biomaterials in chondrogenesis of MSCs. Appropriate stimulations through these factors are crucial in differentiation and proliferation of MSCs. However, use of MSCs for cartilage repair has some drawbacks and risks, such as expression of hypertrophy-related genes in MSCs-derived chondrocytes and consequent calcification or cell death. Nevertheless, the clinical application of MSCs is expected in the future with advanced technology.
