Hypouricemic effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma.
- Author:
Hai-Li SHAN
1
;
Rui-Ping SHAN
2
;
Xu-Chun FU
3
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Dioscorea; chemistry; Disease Models, Animal; Hyperuricemia; chemically induced; drug therapy; Male; Mice; Mice, Inbred ICR; Plant Extracts; pharmacology; Plant Roots; chemistry; Uric Acid; blood
- From: Journal of Zhejiang University. Medical sciences 2015;44(1):49-53
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of ethanol extracts from Dioscoreae Nipponicae Rhizoma on hyperuricemic mice.
METHODSThe hyperuricemia was induced by gavage of hypoxanthine and subcutaneous injection of potassium oxonate (model A) or subcutaneous injection of uric acid (model B) in ICR male mice. The mice in ethanol extracts groups were administrated with Dioscoreae Nipponicae Rhizoma ethanol extracts 5.4 g/kg by gavage, the positive control groups were given with 10 mg/ml allopurinol or 5 mg/ml benzbromarone by gavage, respectively. The plasma uric acid levels were measured by using HPLC.
RESULTSThe plasma uric acid levels of model group, control group and ethanol extract group in model A mice were (40.03±27.24), (4.08±1.47) and (18.10±8.87) g/mL (compared with model group, P <0.05), respectively. The plasma uric acid levels of model group, control group and ethanol extract group in model B mice were (18.57±3.83), (4.29±2.36) and (15.36±2.71) g/mL (compared with model group, P <0.05), respectively.
CONCLUSIONThe ethanol extracts from Dioscoreae Nipponicae Rhizoma have certain hypouricemic effect in hyperuricemic mice induced by hypoxanthine and potassium oxonate or by uric acid.
