Correlation between follicle-stimulating hormone and total procollagen I N-terminal propeptide in perimenopausal women.

Bing Wang; Yan Chen; Yang Song; En-sheng Wang; Dan Zheng; Fan QU; Jian-hong Zhou

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Correlation between follicle-stimulating hormone and total procollagen I N-terminal propeptide in perimenopausal women.

Author: Bing WANG ^{1
,

2} ; Yan CHEN ³ ; Yang SONG ³ ; En-Sheng WANG ³ ; Dan ZHENG ³ ; Fan QU ³ ; Jian-Hong ZHOU ³
Author Information

1. Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
2. Department of Gynecology, Second Hospital of Jiaxing, Jiaxing 314000,China.
3. Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Publication Type:Journal Article
MeSH: Adult; Female; Follicle Stimulating Hormone; blood; Humans; Middle Aged; Peptide Fragments; blood; Perimenopause; blood; Procollagen; blood
From: Journal of Zhejiang University. Medical sciences 2015;44(1):85-89
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the correlation between serum levels of follicle-stimulating hormone (FSH) and total procollagen I N-terminal propeptide (TP1NP) in perimenopausal women.
METHODSTotal 274 women aged 33~60 y with perimenopausal period were enrolled in this study. Serum levels of FSH and TP1NP were detected by electrochemiluminescence.
RESULTSIn 274 perimenopausal women, the average level of TP1NP was (48.99±20.31) ng/mL, which was positively correlated with FSH level (r=0.159, P=0.009). In 40-50 age group, TP1NP level in women with FSH<40 mIU/mL was lower than that in those with FSH≥40mIU/mL [(35.05±18.11) ng/mL vs (51.33±24.67) ng/mL; t=-2.954, P=0.004]. However, in <40 and 50-60 age groups, there were no significant differences in TP1NP levels between patients with FSH<40 mIU/mL and those with FSH≥40 mIU/mL (t=-0.063, P=0.950; t=1.177, P=0.242). Multiple linear regression analysis showed that standardized coefficients of age variable was 0.047 (P=0.448) and standardized coefficients of FSH variable was 0.146 (P=0.019).
CONCLUSIONTP1NP levels showed a certain correlation with FSH in perimenopausal women, especially for women aged 40-50, indicating that high FSH levels may be important factors for osteoporosis in postmenopausal women.