Progress on matrix metalloproteinase in axonal regeneration.
- Author:
Yu-Ying LI
1
;
Yue-Min DING
2
;
Xiong ZHANG
1
Author Information
1. Zhejiang University School of Medcine,Hangzhou 310058,China.
2. School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
- Publication Type:Journal Article
- MeSH:
Axons;
Cicatrix;
Extracellular Matrix;
Matrix Metalloproteinases;
Nerve Regeneration;
Neuroglia;
Spinal Cord Injuries
- From:
Journal of Zhejiang University. Medical sciences
2015;44(1):95-100
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases. MMPs can degrade and remodel extracellular matrix, also active or inactive many molecules attaching to matrix including receptors, growth factors and cytokines, so that injury-induced MMPs can change the extracellular environment to affect the axonal regeneration in central nervous system. In this review, with spinal cord injury (SCI) as an example we discuss the effects of MMPs on inflammation, neuronal viability, extracellular molecules, glial scar and axonal remyelination, which are all important to axonal regeneration.
