Progress on association between low-density lipoprotein receptor and metabolic syndrome.
- Author:
Wen-Yuan JIN
1
;
Zheng-Yan ZHAO
1
Author Information
1. Department of Child Care, Affiliated Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Homeostasis;
Humans;
Lipid Metabolism;
Lipoproteins, LDL;
Metabolic Syndrome;
Receptors, LDL
- From:
Journal of Zhejiang University. Medical sciences
2015;44(1):101-107
- CountryChina
- Language:Chinese
-
Abstract:
Low-density lipoprotein receptor (LDLR) and metabolic syndrome (MS) are closely correlated. Changes in LDLR expression, feedback regulation and degradation, impacts of LDLR deficiency on blood lipid levels, roles of LDLR in islet β cell dysfunction and cholesterol homeostasis dysregulation, expression of LDLR gene nuclear transcription factors and polymorphism of LDLR gene segments are all involved in the development of specific components of MS. In recent years, a variety of targets and intervention mechanisms in relation to LDLR and MS have been extensively studied. Knowledge about association between LDLR and MS may contribute to the development of strategies for prevention and treatment of MS. This article reviews the update on the association between LDLR and MS.
