Effects of DNMT3A gene mutations on prognosis of patients with acute myeloid leukemia: a meta-analysis.
- Author:
Xiao-ping XI
1
;
Ling-xia ZENG
2
;
Fang-fang YU
2
;
Hua-sheng LIU
1
Author Information
- Publication Type:Journal Article
- MeSH: DNA (Cytosine-5-)-Methyltransferases; genetics; Humans; Leukemia, Myeloid, Acute; diagnosis; genetics; Mutation; Prognosis; Risk Factors
- From: Journal of Zhejiang University. Medical sciences 2015;44(2):197-203
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of DNMT3A gene mutation on prognosis of patients with acute myeloid leukemia (AML) by a meta-analysis.
METHODSMethods of Cochrane systematic review was followed by 7 databases,including PubMed, Embase, Ovid, CNKI, CBM, WanFang Data and VIP, were searched for peer-reviewed articles related to DNMT3A gene mutations and prognosis of patients with AML.Then manual retrieval was applied into literature references. After the evaluation of quality and extract of clinical trialliterature data, Stata 11.0 was employed to perform meta-analysis.
RESULTSSeven randomized controlled trials involving 1493 cases were included in the meta-analysis. The prognosis of patients with DNMT3A mutations and without DNMT3A mutations was compared. There was no statistically significant difference in complete remission(CR) rate (OR=1.034, 95%CI: 0.596~1.796, P=0.905 between two groups, but the overall survival (OS（HR=1.990, 95%CI: 1.463~2.510, P=0.000 and disease free survival (DFS) (HR= 2.840, 95%CI: 1.063~4.613, P=0.002) of patients without DNMT3A mutations were longer than those with DNMT3A mutation.
CONCLUSIONDNMT3A gene mutation is an independent risk factor of poor prognosis of patients with acute myeloid leukemia.
