Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis.
- Author:
Zhi-xian LIU
1
;
Er-qing WEI
1
;
Yun-bi LU
1
Author Information
1. Department of Pharmacology, Zhejiang University, School of Medicine, Hangzhou 310058, China
- Publication Type:Journal Article
- MeSH:
Cadherins;
Epithelial-Mesenchymal Transition;
Humans;
MicroRNAs;
Neoplasm Metastasis;
Neoplasm Recurrence, Local;
Neoplasms;
Signal Transduction;
Transcription Factors;
Transforming Growth Factor beta;
Wnt Signaling Pathway
- From:
Journal of Zhejiang University. Medical sciences
2015;44(2):211-216
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
