Research advances on ubiquitin C-terminal hydrolase in oncogenesis and progression.
- Author:
Juan YU
1
;
Wei-lin CHEN
1
Author Information
1. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Carcinogenesis;
Disease Progression;
Humans;
Neoplasms;
Ubiquitin;
Ubiquitin Thiolesterase
- From:
Journal of Zhejiang University. Medical sciences
2015;44(2):217-222
- CountryChina
- Language:Chinese
-
Abstract:
By regulating the ubiquitination and deubiquitination of key proteins, ubiquitin-proteasome system mediates a variety of cellular activities. Ubiquitin C-terminal hydrolase (UCH) is a deubiquitinating enzyme which can remove ubiquitin chains at the end of ubiquited proteins. The abnormal expression of UCH has been found in a variety of tumor tissues, indicating that it participates in the process of tumor development. Here we review the characteristics of UCH members and current understanding about the role of UCH in tumor development, and the potential target for cancer treatment.