Malnutrition in early life and cardiovascular disease in adulthood.
- Author:
Lin-jiang LAO
1
,
2
;
Li-yan ZHANG
1
;
Li-zhong DU
1
;
Author Information
1. Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2. 2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Blood Pressure;
Cardiovascular Diseases;
epidemiology;
Disease Models, Animal;
Humans;
Malnutrition
- From:
Journal of Zhejiang University. Medical sciences
2015;44(3):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiological and experimental studies have demonstrated that the risk of cardiovascular disease (CVD) in adulthood is influenced by the environment in early life. Intrauterine and early postnatal malnutrition and the following catch-up growth have a long-term effect on blood pressure and endothelial function in adulthood. Well-established prenatal or/and postnatal animal models are used to study the impact of different nutritional intervention on CVD in adulthood. This article reviews the early original cause of chronic CVD in adulthood with the hypothesis of DOHaD (the developmental origins of health and disease), and proposes possible preventions in early life on the basis of this theory.
