Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C.
- Author:
Xiao-rong MAO
1
;
Li-ting ZHANG
1
;
Ni JIANG
1
;
Ping XIAO
1
;
Xue-bin PENG
1
;
You-cheng ZHANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; China; Female; Genotype; Hepacivirus; genetics; Hepatitis C, Chronic; virology; Humans; Male; Randomized Controlled Trials as Topic; Viral Load
- From: Journal of Zhejiang University. Medical sciences 2015;44(4):417-422
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C (CHC).
METHODSThis randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China. SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA.
RESULTSHCV 1 genotype (56.80%) was the most common genotype. The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China. HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively (all P <0.05). There was no statistical significance between different genders in other regions. The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients.
CONCLUSIONThere are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.
