Research progress in toxicology of molecular targeted anticancer drugs.
- Author:
Xiao-e LOU
1
;
Min CHEN
1
;
Bo YANG
1
Author Information
1. Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
toxicity;
Humans;
Molecular Targeted Therapy
- From:
Journal of Zhejiang University. Medical sciences
2015;44(5):473-478
- CountryChina
- Language:Chinese
-
Abstract:
Drug therapy is essential for cancer treatment. The molecular targeted anticancer drugs develop rapidly in recent years, since the effectiveness of traditional chemotherapy is unsatisfactory and the adverse reactions are high. However, molecular targeted anticancer drugs would damage the function of heart, liver or lung, and may cause adverse effects such as hand-foot syndrome, which restrains their clinical application. Therefore, it is critical for pharmaceutical toxicology to study the toxicity, the related mechanisms and the preventive measures of molecular targeted anticancer drugs.
