Antiepileptic effect of low frequency stimulation in kindling rats.

Yang Liu; Yi Wang; Zheng-hao XU; Zhong Chen

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Antiepileptic effect of low frequency stimulation in kindling rats.

Author: Yang LIU ¹ ; Yi WANG ² ; Zheng-hao XU ³ ; Zhong CHEN ²
Author Information

1. Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China.
2. Department of Pharmacology, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China.
3. Department of Pharmacology, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China
Publication Type:Journal Article
MeSH: Amygdala; Animals; Deep Brain Stimulation; Kindling, Neurologic; Rats; Seizures; therapy
From: Journal of Zhejiang University. Medical sciences 2015;44(5):539-545
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the antiepileptic effects of various stimulation modes of low-frequency stimulation(LFS) on the kindling rats.
METHODSStimulating electrodes were implanted in the amygdala and current with constant intensity was applied to evoke kindling-induced seizures. The antiepileptic effect of LFS by open loop stimulation(before kindling), closed loop stimulation(immediately after kindling) and different forms of closed loop stimulation(whole stage after kindling and early stage after kindling) were investigated in amygdala kindled rats.
RESULTSThe closed loop LFS of whole stage after kindling can significantly inhibited seizure stages(P<0.01) and reduced afterdischarge duration(P<0.05). The closed loop LFS of early stage after kindling can significantly suppress the seizure stages, mainly in stages 0-3(P<0.05 or P<0.01). The open loop low-frequency stimulation did not inhibit the seizure stage during kindling acquisition(P>0.05).
CONCLUSIONThe antiepileptic effect of low frequency stimulation may have a mode-dependent effect. It may be helpful for the deep brain stimulation as a promising approach applied to clinical antiepileptic therapy in the future.