Research progress in kidney dendritic cells.
- Author:
Rui-Ling CHEN
1
,
2
;
Jian-Ping PAN
3
Author Information
1. Zhejiang University City College School of Medicine, Hangzhou 310015, China
2. Department of Pathogen Biology, Zhejiang University School of Medicine, Hangzhou 310058, China.
3. Zhejiang University City College School of Medicine, Hangzhou 310015, China.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Dendritic Cells;
cytology;
immunology;
Epithelial Cells;
cytology;
Humans;
Inflammation;
immunology;
Kidney;
cytology;
Kidney Diseases;
immunology;
Lupus Nephritis;
immunology;
Pyelonephritis;
immunology
- From:
Journal of Zhejiang University. Medical sciences
2015;44(5):584-588
- CountryChina
- Language:Chinese
-
Abstract:
Kidney dendritic cells(DC) play important roles in the pathogenesis of kidney diseases. Kidney DC presents anti-inflammatory effects in certain kidney diseases, sometimes presents pro-inflammation in other diseases, and sometimes their effects are changing in different stages of the disease, suggesting that the differentiation and function of kidney DC may be influenced by microenvironment. This article reviews the origin and distribution of kidney DC subsets and their roles in the pathogenesis of kidney diseases such as lupus nephritis and pyelonephritis, and the functional regulation of kidney DC by proximal tubule epithelial cells.
