Preventive effect of chitosan on capsular contracture after implantation of silicone gel-filled mammary implants in rats.
- Author:
Ying-Jun YAN
1
;
Qun QIAO
;
Jia-Ming SUN
;
Zhi-Fei LIU
;
Ke-Xin SONG
;
Ying YUE
;
Bao-Dong SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Breast Implantation; Breast Implants; adverse effects; Chitosan; therapeutic use; Contracture; etiology; prevention & control; Female; Mammary Glands, Animal; surgery; Rats; Rats, Sprague-Dawley; Silicone Gels; adverse effects
- From: Chinese Journal of Plastic Surgery 2005;21(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the preventive effect of chitosan on capsular contracture after implantation of silicone gel-filled mammary implants in rats.
METHODS18 SD female rats were divided into three groups randomly. Small silicone gel-filled mammary implants were implanted under each side of latissimus dorsi muscle. Chitosan was injected into left cavities as experimental sides, and nothing was injected into right cavities as control sides. 4, 8 and 12 weeks postoperation, specimens were dissected and observed using light microscope, and area density of collagen both type I and type III were also detected.
RESULTSFibrous capsules around implants consist of two layers: dense layer and loose layer. 4 weeks postoperation, total thickness of the experimental sides was less than that of the control sides (P < 0.01). Area density of collagen either type I or type III of the experimental sides was lower than that of the control sides (P < 0.01). Both 8 and 12 weeks postoperation, total thickness of the experimental sides was less than that of the control sides (P < 0.05). Area density of collagen type I of the experimental sides was lower than that of the control sides (P < 0.05). Area density of collagen type III was of no statistical difference between the experimental sides and the control sides (P > 0.05).
CONCLUSIONSChitosan can remarkably prevent capsule contracture during the early period after implantation of silicone gel-filled mammary implants.
