OBJECTIVEFrom the point of holistic integrative medicine, the D(L)CO depends on not only normal respiratory and circulatory functions, but also an optional matching between them. However, due to the limitation of traditional systemic physiology, the D(L)CO always be classified as lung functional parameter to be analyzed and interpreted. Because ignoring the circulatory system function, so it will certainly have some misunderstandings.

METHODSBased on the Holistic Integrative Medicine, under the control of neurohumoral, respiratory, circulatory and metabolic systems work together, we discussed the diffusion function. We analyzed the change of D(L)CO in the patients with cardiac dysfunction, especially the heart failure.

RESULTSThe D(L)CO, CO gas,diffusion from lung circulating blood, depends on the normality of respiratory and circulatory systems and their matching. We analyzed the reasons of D(L)CO for characteristic pathophysiological changes of patients with heart failure.

CONCLUSIONThe normal D(L)CO depends on a good matching of normal respiratory and circulatory systems. For heart failure, the respiratory and circulatory systems matching is poor. Due to dominant limitation of left ventricle pump function, pulmonary blood volume may slightly increased, but combination of all reduced pulmonary blood flow rate, thicked diffuse member and increased diffusion distance etc. suggest that patients with heart failure should have a decreased, rather than increased, D(L)CO.